Seven of the most frequent spinocerebellar ataxias (SCAs) are caused by a pathological expansion of a cytosine. adenine and guanine (CAG) trinucleotide repeat located in exonic regions of unrelated genes. which in turn leads to the synthesis of polyglutamine (polyQ) proteins. PolyQ proteins are prone to aggregate and form intracellular inclusions. https://www.chiggate.com/color-charm-050-cooling-violet-supply/