Abstract There is accumulating evidence of endothelial dysfunction. muscle and cerebral hypoperfusion in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). In this paper we deduce the pathomechanisms resulting in central nervous pathology and the myriad of neurocognitive symptoms. We outline tentative mechanisms of impaired cerebral blood flow. https://www.spidertattooz.com/JuneShine-Prickly-Weekend-Friend-16oz-can-6-ABV/